Since 2009, different approaches have been attempted at Infinitec to overcome these problems by providing “selective” delivery not to affected skin areas, but to target the active only to those target cells affected as the ideal solution. The quest for a real cosmetic bullet that skin care customers can fully understand. For more than 8 years, we have been working on actively-targeted delivery systems (renowned as The Cosmetic Drone). Definitely the most advanced release system in the world of cosmetics, the ultimate design in cosmetic active carriers.
Active targeting, also called ligand-mediated targeting, involves utilizing affinity ligands on the surface of carrier particles for specific retention and uptake by the targeted cells. To that end, ligands are selected to bind surface receptors overexpressed in targeted cell. The design of actively-targeted particle active carriers is complex because the particle architecture, the ligand conjugation chemistry and the types of ligand available, skin penetration all contribute to the stability and efficacy of the system. And, also, legal compliance and cosmetic acceptability.
The fundamentals of active targeting involve utilizing affinity ligands on the surface of carrier particles for specific retention and uptake by the targeted cells. The main mechanism behind active targeting is the recognition of the ligand by its target substrate. Cosmetic Drones ® ligands are peptides and target structures are receptors on the surface of cells. The ability to vectorize capsules to the target cells in a selectively way, especially when placing the delivery system within the target has great advantages that result in greater efficiency of the system. By combining the best carrier, targeting capability and controlled active release within cells, the therapeutic concentration of use is at its lowest.
At present, Cosmetic Drones can be actively-targeted to 5 different target receptors (cells): keratinocytes, fibroblasts, melanocytes, skin neurons and adipocytes and release a large number of different active ingredients for multiple cosmetic applications.