Combinatorial Chemistry Platform

TecnologiaPlataformaQumicaCombinatoria

Combinatorial Chemistry Platform (synthesis of peptides)

Biomimetic peptides
Products: ECM Moduline, TIMP, Liposuctionine

Peptides are made up of individual amino acids. Their sequence and the arrangement of their chains determine their function. Biomimetic peptides are identical to the skin’s peptides, and act on the physiological mechanisms of the skin with a high specificity. Biomimetic peptides are not complete copies of the amino acid sequence; rather they are small, active sections. Peptides can be used to identify and optimize leads for a wide range of targets.

Neuropeptides
Products: Bronzing SF, BONT-L Peptide

The cutaneous neuro-immuno system (CNIS) is a novel concept of cutaneous biology. Cosmetic problems of the skin are sorted out and they become now achievable when interacting with the Cutaneous Nervous System. Neuropeptides or “intelligent cosmetics” consist of the application of topic administration of synthetic neuropeptides whose neurophysiologic action performs cosmetic and aesthetic benefits as well as wellness benefits.

Peptidic Hybridation
Product: Detoxiquin

Synthetic peptides are joined to another molecule in order to obtain a synergistic or complementary effect. They form a type of “hybrid peptide”. In traditional peptide chemistry, building blocks are introduced with all functional groups but one protected. The formation of amine bonds in solid phase and other reactions are easy, for example, ester formation, deprotection (Ally/Alloc groups, Fmoc, etc). The binding is not placed in the peptide sequence or carried out in the solid phase without the use of base to avoid side reactions. Fewer changes in the molecule composition are made.

Peptidic Conjugation
Products: Golden Collagenine, Platinum MatrixEM, Diamond Sirt

Peptides are conjugated to other particles by using complementary technologies. First, peptides are synthesized to obtain a given synthetic sequence with a specific activity. Then, the particle is conjugated to the obtained synthetic peptides in order to stabilize and deliver them to the target cell in an improved and sustainable release profile.

Tissue Engineering
Product: Renaissance

Tissue regeneration is the instrumental line to follow for repair, substitution and tissue regeneration itself by using new technologies that emerge from several scientific disciplines including biomaterials, dermatology, biochemistry and biotechnology.

New and unprecedented solutions for tissue lesions have become possible by means of cellular and tissue engineering and, in particular, by using biological materials both natural and synthetic in order to provide structure and shape for tissue assembly. In skin, it essentially plays a role in the recovery from damage and aging.

Self-assembling peptides are among the most common biomolecules that, in recent years, have been considered for biomedical purposes. Peptides have been synthesized to form 3D fibril scaffolds with a bioactive surface capable of inducing specific reactions and build new structures to help tissues to recover.

Many research groups have focused their investigation in synthesizing self-assembling peptides mimicking the extracellular matrix (ECM) structure and evaluate their potential application in cosmetic tissue regeneration. INFINITEC´s first approach to tissue engineering comes with Renaissance.